Grant/Award Number: G: 628130Ajwa date, doxorubicin, molecular docking, nephroprotective, nephrotoxicity, phytochemical1 | I NTRO D U C TI O NIncreasing in prevalence globally, chronic kidney illness is a substantial public health concern that will potentially lead to kidney failure. Kidney disease entails a progressive reduction in kidney function attributable to nephron decreases (Hren et al., 2013). Even though it has powerful antitumor effectiveness, doxorubicin (DOX) is restricted as achemotherapeutic drug due to its cardiac, pulmonary, testicular, and renal toxicity (Fadilliolu et al., 2003; Sabbah et al., 2018). In chronic kidney illness animal models, DOXinduced nephrotoxicity is renowned and widespread; its detrimental effect is managed by way of proximal tubules’ discriminatory cellular injury via mechanisms that stay because the core (Grant et al., 2019). Regardless of doxorubicin’s acute cellular toxicity mechanism ambiguity, ROS is really a primary elementThis is an open access report below the terms from the Inventive Commons Attribution License, which permits use, distribution and reproduction in any medium, supplied the original work is correctly cited. 2023 The Authors. Meals Science Nutrition published by Wiley Periodicals LLC. 1584 wileyonlinelibrary.com/journal/fsn|Meals Sci Nutr. 2023;11:1584598.BAOTHMAN et al.|of DOX toxicity; hence, the variables that handle this oxidative harm are comprehensively researched (Reddy et al., 2007). DOX injection produces hydrogen peroxide, superoxide anions, and hydroxyl radicals. DOX is transformed into a semiquinone no cost radical by NADPHcytochrome P450, which then initiates superoxide anion and hydroxyl radicals’ generation, creating LPO (Oz Ilhan, 2006).Di(1H-pyrrol-2-yl)methane Price While many studies have examined the DOXinitiating molecular mechanism, you will discover gaps surrounding its causal elements. Possibly, the basis of this is DOX creating DOX semiquinone. While the resultant semiquinone radical does not possess a long life span, it creates a torrent of reactions creating ROS upon reacting with O2 ROS (ElShitany et al., 2008; Liu et al., 2007; Mohan et al., 2010; Raskovi et al., 2011). Evidently, applying doxorubicin results in enhanced production of superoxide molecules, hydrogen peroxide, and hydroxyl radicals, which can quickly interact with membrane lipids, resulting in LPO (Oz Ilhan, 2006). LPO is often a core component of your toxic indicators of DOX administration and is assessed in line with MDA intensities. In rats, DOXinduced nephrotoxicity exhibits extreme renal LPO (Akyol et al., 2014; Yagmurca et al., 2004). Date palm fruits (DPFs) are eaten in a lot of nations and are specifically essential in Middle Eastern and North African nations. DPF extracts contain several pharmacological properties, such as antiallergic (Karasawa Otani, 2012), antibacterial (Zhang et al.31420-52-7 site , 2013), antifungal (Boulenouar et al.PMID:25959043 , 2011), antioxidants (El Arem et al., 2014), anticancer (Karasawa Otani, 2012), antiinflammatory (BorochovNeori et al., 2015), antimicrobial (Mahdhi et al., 2013), cardioprotective (Mubarak et al., 2018a; Sabbah et al., 2018), immuneboosting (Karasawa et al., 2011), nephroprotective (Wang et al., 2019), and neurologically protective (Pujari et al., 2011). Furthermore, study has shown that DPF extract can primarily hunt for oxidants resulting from its antioxidants and antimutagenic compounds (Allaith, 2008; Shireen et al., 2008). Recently, organic antioxidant consumption has generated vast interest as a implies of averting oxidat.